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*Agaricus blazei* is rich in polysaccharides, proteins, nucleic acids, lipids, saponins, tannins, sterols, minerals, trace elements, and essential amino acids, among other constituents; notably, *Agaricus blazei* polysaccharides serve as the primary active compounds responsible for its therapeutic effects. It demonstrates significant efficacy in areas such as anti-tumor activity, blood glucose reduction, anti-fatigue effects, and antioxidant properties, and can be utilized in the treatment of conditions such as cancer, heart disease, and obesity.

1. Antitumor

he polysaccharide chains of polysaccharides can act directly on tumor cells by inhibiting their proliferation and differentiation, thereby regulating cellular growth and senescence; furthermore, they can exert anti-tumor effects by enhancing immunity or inducing tumor cell apoptosis. Four types of *Agaricus blazei* polysaccharides were obtained through hot water extraction and ultrasonic extraction at pH 4 and pH 7, respectively. A study investigating their effects on tumor-induced gamma-globulin levels revealed that *Agaricus blazei* polysaccharides possess anti-tumor activity.

2. Immunomodulation

*Agaricus blazei* polysaccharides possess immunomodulatory activity. The water-soluble polysaccharide from *Agaricus blazei* (ABP-AW1) can significantly promote the proliferative responses of splenic T and B lymphocytes in immunodeficient mice.